Ignite Technology Transfer Office

Technologies Available for License from Ignite NUI Galway

  • Cost-effective enablement of Tissue Regeneration and Organogenesis

    NUI Galway has developed and patent-protected a technology that enables a greater than 20-fold increase in extracellular matrix deposition within 48h of culture. This robust approach has the potential to produce tissues in vitro, with a precision and stoichiometric efficiency still unmatched by man-made devices.

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  • OSNA (Open Sensor Network Authentication)

    An exciting solution and licensing opportunity in the fields of Device Authentication and Cyber Security Solutions for the Internet of Things (IoT).

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  • VASGARD (Vein Screening System)

    A Small, wearable and comfortable sensor system that monitors the primary cause of varicose veins, venous oedema and venous leg ulcers.

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  • Wi-Sync - Delivering Quality Time over WiFi

    A low-cost platform for the provision of low-millisecond synchronisation accuracies over highly active Wi-Fi networks when used in conjunction with a time protocol such as NTP.

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  • OsteoAnchor

    OsteoAnchor is a novel orthopaedic implant surface technology, with superior fixation performance across a range of applications, including hip and knee replacements.

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  • Novel microRNA Biomarkers for detection and characterisation of breast cancer

    Our Breast Cancer Research team at NUI Galway has identified, characterized and patent-protected a number miRNAs biomarkers, with highly aberrant expression levels in women with breast cancer. Blood sample functionality is a particularly attractive feature from the perspective of the patient.

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  • NFBfect – a superior transfection reagent

    An NUI Galway Biomaterials Research team has developed a novel polymer, with improved transfection efficiency, reduced cytotoxicity and significant potential for gene therapy application.

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  • Wet Tissue Adhesive technology

    An NUI Galway Biomaterials Research team has recently developed a novel adhesive polymer, suitable for internal use, is biodegradable and has capacity to customize the setting profile.

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  • The Multi-channel Nerve Conduit

    An NUI Galway Biomaterials Research team has developed and patent-protected a multi-channel conduit solution, which enables significantly improved guidance of nerve growth, repairing nerve gaps of up to 5cm in length.

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  • Degradable Hollow Microspheres for Targeted Therapeutic Delivery

    An inter-disciplinary Research team has developed a novel, robust process for producing hollow microspheres of defined size and shape using a range of biocompatible materials. Extensive studies show the microspheres to be non-toxic and deliver a significant load to target tissue.

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  • Epigenetic Drug Discovery Tool

    A research team with extensive experience in chromatin biology, and has recently developed a significant library of over 400 recombinant histone mutants providing an opportunity to fully understand and characterise epigenetic activities on histones in screening and validating new compounds and genes.

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  • Bioavailable Iron Fortification (“BIRF”) Technology

    A Plant Biotech Research group at NUI Galway have identified and developed a novel “single-gene” solution, which provides an 8-fold higher uptake, accumulation and bioavailability of iron across different species.

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  • Semi-automated whole blood assay for screening immune-modulatory compounds

    Semi-automated assay developed utilizing whole blood to identify immune-modulatory effects of compounds. Rapid turnaround times seen. Applications in drug screening and therapeutic uses.

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  • Novel nucleic acid target for detection and identification of bacteria and fungi

    Novel gene target identified by the Molecular Diagnostic Research Group within NUIG which is capable of detecting, identifying and distinguishing between closely related bacteria and fungi. An effective marker to drive the development of a suite of in vitro diagnostic assays.

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  • Novel biomarker for diagnosis and prognosis of Multiple Myeloma

    A team of clinicians and scientists at NUIG have identified a novel biomarker with diagnostic and prognostic abilities, predicting relapse/refractory disease potential and patient survival rates.

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  • Enzyme tool for analyzing complex polysaccharides

    Scientists at NUI Galway have developed a novel enzyme for use in analyzing complex polysaccharides. This enzyme has selectivity for cleavage of oligomannose and high-mannose structures, without cleaving and releasing hybrid or complex-structures allowing for more detailed analysis.

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  • Novel antibody for detection of Galactosyl-α-(1,3)-Galactose

    Non-human Galactosyl-α-(1,3)-Galactose, produced for example following large-scale biologics manufacture, is a major cause of the hyper acute response. Scientists at NUI Galway have developed a novel stable recombinant antibody to detect this with a high degree of specificity.

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  • Recombinant Chromatin Substrates – Supporting Epigenetic Drug Discovery

    Recent developments in our understanding of the biochemistry of disease conditions such as cancer highlight significant correlations with epigenetic factors and proteins such as the histones. This offers significant potential for the development of new therapies, by targeting inhibition of chromatin-active proteins. To date, such efforts have been restricted by the availability of screening tools, which can take time to develop.

    A highly skilled Research team, with extensive experience in chromatin biology, has recently developed a significant library (436) of recombinant histone mutants, in which all residues in the core histones are mutated to alanine. In total 180 potential sites of post-translational modifications are covered. These very stable mutants provide the investigator with a complete assay substrate kit for detailed characterisation of chromatin activity.

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  • A significant breakthrough in the quest for cost-effective Tissue Regeneration and Organogenesis

    Significant costs associated to prolonged culture times has restricted in vitro tissue generation’s impact on billion-dollar tissue repair markets. A highly innovative Biomaterials Research team at NUI Galway has recently developed and patent-protected a simple, yet highly productive process for achieving a 20-fold improvement in matrix deposition within 48h of in vitro culture. This platform has the genuine potential to make the rapid production of a variety of tissue types a reality, including tendon, cornea, skin, peripheral nerve, cartilage and bone.

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  • OSNA Open Sensor Network Authentication

    Security is as important in smart object and sensor networks as it is in traditional computer networks, if not more so. By leveraging elliptic curve cryptography and well-established X.509 public key infrastructure security mechanisms, adapting them appropriately for resource-constrained environments, we enhance the security of smart objects, their data and the networks in which they participate.

    Using lightweight embedded digital certificates allows for off-line authentication of (wireless) sensor network devices (SND). OSNA is a platform- and manufacturer-independent solution for secure M2M communication, supporting multiple protocol stack and hardware implementations.

    The system allows for on-demand issuing of certificates via the cloud based certificate and registration authority modules. This gives the ability for streamlined integration into the manufacturing process through ease of flashing and programming of wireless sensor devices with certificates and security keys on the manufacturing floor. Library support is available for full X.509 interoperability.

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  • Novel microRNA Biomarkers for detection of Luminal A breast cancer

    Breast cancer is the most commonly diagnosed cancer in women both in the developed and the developing world. U.S. figures highlight that 1 in 8 (12%) women developing invasive breastcancer during their lifetime, with 17.4% of these dying as a result of the disease. Early diagnosis, aswell as accurate prognostication are critical to survival. Global health and potentially significant commercial rewards make high performance breast cancer biomarkers a valuable commodity. We have identified three novel miRNAs markers, miR-181a,miR-195 and miR652, with highly aberrant expression levels in women with breast cancer. Blood sample functionality is a particularly attractive feature from the perspective of the patient.

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  • Multi-channel Conduit

    Professor Pandit and his team at NUI Galway have developed and optimised a multi-channel conduit solution, which enables significantly improved guidance of nerve growth, repairing nerve gaps of up to 5cm in length. Such performance, along with the flexibility to control the rate of biodegradation, distinguishes this Multi-channel Conduit from any other conduit or solution currently on the market.

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  • Bone Adhesive Technology

    Bio-inspired polymeric adhesive for sternum closure

    Improved bone fixation strength

    Easy to operate compared to traditional wire fixation

    Biodegradable & safe for internal use Improved patient comfort

    Optimised setting timeline to facilitate emergency access

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  • Polymer with improved transfection efficiency

    At NUI Galway, we have recently developed a synthesis platform suitible for the production of specifically-designed cationic polymers. We have demonstrated these polymers to deliver improved transfection effeciency and cytotoxicity performance when compared to currently available gold standard gene delivery reagents. 'NFBfect' is an example of one such polymer.

    Our platform is capable of synthesising polymers with impressive biodegradable properties [intracellular] and the specific addition of modifiable functional groups, making antibody (or indeed moieties of a variety of other applications) attachment a genuine prospect.

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  • Benzomacrolactone-based Peptide Mimetic Drugs

    Insufficient pharmacokinetics following administration of the hormone somatostatin has led to the synthesis of both peptideand non -peptidemimetics. Such drugs are used for the treatment of arrange of conditions such as neuroendocrine tumors, acromegaly and increasingly, polycystic diseases of the liver and kidney. Treatments currently on the market including Sandostatin (Novartis), with 2010 sales in the U.S. inexcess of $1.2billion*, and Somatuline (Ipsen) are restricted in their requirement for parenteral administration.

    Prof. Paul Murphy and his Research team at NUI Galway have recently identified the potential of using abenzomacrolact onescaffold to develop non peptidal somatost at inmimetics, with excellent activity and suitable for oral delivery.

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